Purchase
Description
Dulaglutide biosimilar is a fusion protein that consists of 2 identical, disulfide-linked chains, each containing an N-terminal GLP-1 analog sequence covalently linked to the Fc portion of a modified human immunoglobulin G4 (IgG4) heavy chain by a small peptide linker and is produced using mammalian cell culture. The GLP-1 analog portion of dulaglutide is 90% homologous to native human GLP-1 (7-37). Structural modifications were introduced in the GLP-1 part of the molecule responsible for interaction with the enzyme dipeptidyl-peptidase-IV (DPP-4). Additional modifications were made in an area with a potential T-cell epitope and in the areas of the IgG4 Fc part of the molecule responsible for binding the high-affinity Fc receptors and half-antibody formation. The overall molecular weight of dulaglutide is approximately 63 kilodaltons.
Dulaglutide biosimilar is supplied at a concentration of 3 mg/mL as a clear, colorless, sterile solution, which contains 0.14 mg/mL citric acid anhydrous, 46.4 mg/mL mannitol, 0.20 mg/mL polysorbate 80, 2.74 mg/mL trisodium citrate dihydrate.
Statement: this product is used for R&D only, not for clinical usage.
Properties
|
Name
|
Dulaglutide biosimilar
|
|
CAS
NO.
|
923950-08-7
|
|
Type
|
Fusion
protein
|
|
Source
|
Human
|
|
Target
|
GLP-1
|
|
Clone
|
Monoclone
|
|
Molecular
Weight
|
63 kDa
|
|
Formula
|
C2646H4044N704O836S18
|
|
Antibody
Form
|
Purified immunoglobulin
|
|
Physical
Form
|
Solution
|
|
Grade
Standard
|
Medicine Grade
|
|
Place
of Origin
|
China (Mainland)
|
|
Storage
|
-70±15℃ for long-term
storage, 2-8℃ for short-term storage, away from light.
|
Supply Ability
20 kilogram per year, Minimum order quantity is 1 gram.
Price
Inquiry
Material Safety Data Sheet
If you need more information, please contact us.
Certificate Of Analysis
/en/UploadFile/file/201805/20180508153931193119.rar
Detail information about the product please refer the website below：
https://en.wikipedia.org/wiki/Dulaglutide
|
