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Description
ACTEMRA (Tocilizumab) is a recombinant humanized anti-human interleukin 6 (IL-6) receptor monoclonal antibody of the immunoglobulin IgG1κ (gamma 1, kappa) subclass with a typical H2L2 polypeptide structure. Each light chain and heavy chain consists of 214 and 448 amino acids, respectively. The four polypeptide chains are linked intra- and inter-molecularly by disulfide bonds. Tocilizumab has a molecular weight of approximately 148 kDa. The antibody is produced in mammalian (Chinese hamster ovary) cells.
Tocilizumab is supplied as a sterile, preservative-free, clear, colorless to pale yellow liquid, with a pH of about 6.5 at a concentration of 20 mg/mL. Which contains 15 mmol/L phosphate buffer, 0.5 mg/mL polysorbate 80, and 50 mg/mL sucrose.
Properties
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Name
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Tocilizumab
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CAS
NO.
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375823-41-9
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Type
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Whole
antibody
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Source
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Humanized (from mouse)
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Target
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IL-6
receptor
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Clone
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Monoclone
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Molecular
Weight
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148 kDa
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Formula
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C6428H9976N1720O2018S42
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Antibody
Form
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Purified immunoglobulin
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Physical
Form
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Solution
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Grade
Standard
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Medicine Grade
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Place
of Origin
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China (Mainland)
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Storage
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-70±15℃ for long-term
storage, 2-8℃ for short-term storage, away from light.
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Supply Ability
20 kilogram per year, Minimum order quantity is 1 gram.
Price
Inquiry
Material Safety Data Sheet
If you need more information, please contact us.
Certificate Of Analysis
/en/UploadFile/file/201805/20180508155142724272.rar
Detail information about the product please refer the website below：
https://en.wikipedia.org/wiki/Tocilizumab
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